HEPATITIS C CARE PATHWAY IN CEARÁ
TACKLING THE DISEASE AND PROSPECTS FOR ELIMINATION
DOI:
https://doi.org/10.54620/cadesp.v19i1.2290Keywords:
Hepatitis C, Mortality, Epidemiologic surveillance, Adherence to treatment, Liver transplantationAbstract
Objective: To evaluate the hepatitis C care cascade in Ceará by diagnosing the current stage of the state regarding the World Health Organization's elimination targets. Methods: Retrospective, ecological, analytical study assessing hepatitis C in Ceará from 2000 to 2024 regarding case notifications, treatments, liver transplants, and deaths. Local, state, and national databases were used. Results: It is estimated that 44,837 individuals have been infected with hepatitis C in Ceará. Only 2,893 cases were reported from 2000 to 2023. Of these, 1,734 (61.8%) patients were treated with direct-acting antiviral drugs. There were 560 liver transplants and 560 deaths reported due to hepatitis C. Conclusions: Ceará reported a small fraction of the estimated hepatitis C cases and treated most of them. The low number of deaths and notifications suggests the need to expand testing and surveillance for this disease in Ceará, aiming for elimination by 2030.
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Taha G, Ezra L, Abu-Freha N. Hepatitis C elimination: opportunities and challenges in 2023. Viruses. 2023 Jun 22;15(7):1413. DOI:10.3390/v15071413. DOI: https://doi.org/10.3390/v15071413
Roberts MJ, McCaughan GW, Jones DRG, et al. Liver transplantation for hepatitis C virus-related cirrhosis: a global perspective. Liver Transpl. 2015;21(2):163-72. DOI:10.1002/lt.24014. DOI: https://doi.org/10.1002/lt.24014
Brasil. Ministério da Saúde. Departamento de HIV/Aids, Tuberculose, Hepatites Virais e Infecções Sexualmente Transmissíveis. Boletim Epidemiológico - Hepatites Virais 2024 [Internet]. Brasília: Ministério da Saúde; 2024 [citado 2025 Jun 21]. Número Especial. Disponível em: https://www.gov.br/aids/pt-br/central-de-conteudo/boletins-epidemiologicos/2024/boletim-epidemiologico-hepatites-virais-2024/view
Lee MH, Yang HI, Yuan Y, L'Italien G, Chen CJ. Epidemiology and natural history of hepatitis C virus infection. World J Gastroenterol. 2014 Jul 28;20(28):9270-80. DOI:10.3748/wjg.v20.i28.9270.
Celestino PLO, Silva ACB, Quintela ALB, Egidio BCG, Neto EP de M, Cortizo GS, et al. Recent advances in hepatitis viral treatment: effectiveness of antiviral therapies and impact on liver cancer prevention. Braz J Health Rev. 2024;7(5):1-10. DOI:10.34119/bjhrv7n5-052. DOI: https://doi.org/10.34119/bjhrv7n5-052
Mayberry J, Lee WM. The revolution in treatment of hepatitis C. Med Clin North Am. 2019;103(1):43-55. DOI:10.1016/j.mcna.2018.08.007. DOI: https://doi.org/10.1016/j.mcna.2018.08.007
Salari N, Kazeminia M, Hemati N, Ammari-Allahyari M, Mohammadi M, Shohaimi S. Global prevalence of hepatitis C in general population: a systematic review and meta-analysis. Travel Med Infect Dis. 2022;46:102255. DOI:10.1016/j.tmaid.2022.102255. DOI: https://doi.org/10.1016/j.tmaid.2022.102255
Te HS, Jensen DM. Epidemiology of hepatitis B and C viruses: a global overview. Clin Liver Dis. 2010 Feb;14(1):1-21. DOI:10.1016/j.cld.2009.11.009. DOI: https://doi.org/10.1016/j.cld.2009.11.009
Pereira LM, Martelli CM, Moreira RC, et al. Prevalence and risk factors of hepatitis C virus infection in Brazil, 2005 through 2009: a cross-sectional study. BMC Infect Dis. 2013;13:60. DOI:10.1186/1471-2334-13-60. DOI: https://doi.org/10.1186/1471-2334-13-60
Gonzalez MP et al. Carga de infecção por hepatite C no Brasil após pandemia de covid-19 - uma abordagem de modelo matemático [internet] [resumo]. Braz J Infect Dis. 2023 [citado em 21 jun. 2025]; 27(S1): 136. Disponível em: https://www.bjid.org.br/en-carga-de-infeccao-por-hepatite-articulo-S1413867023003306 DOI: https://doi.org/10.1016/j.bjid.2023.103070
Benzaken AS, Girade R, Catapan E, et al. Hepatitis C disease burden and strategies for elimination by 2030 in Brazil: a mathematical modeling approach. Braz J Infect Dis. 2019;23(3):182-90. DOI:10.1016/j.bjid.2019.04.010. DOI: https://doi.org/10.1016/j.bjid.2019.04.010
Brasil. Ministério da Saúde. Protocolo Clínico e Diretrizes Terapêuticas para Hepatite C [Internet]. Brasília: Ministério da Saúde; 2019 [citado 2025 Jun 21]. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/hepatites/pcdt-da-hepatite-c/view
Brasil. Ministério da Saúde. Plano para eliminação da hepatite C no Brasil [Internet]. Brasília: Ministério da Saúde; 2018 [citado 2025 Jun 21]. Disponível em: https://www.gov.br/aids/pt-br/central-de-conteudo/publicacoes/2019/plano-para-eliminacao-da-hepatite-c-no-brasil
World Health Organization. Hepatitis C guidelines: diagnostic, treatment and care [Internet]. Geneva: WHO; 2016 [citado 2025 Jan 26]. Available from: https://www.who.int/hepatitis/publications/hepatitis-c-guidelines/en/
World Health Organization. Global health sector strategy on viral hepatitis 2016-2021 [Internet]. Geneva: WHO; 2016 [citado 2025 Jan 26]. Available from: https://www.who.int/hepatitis/strategy2016-2021/en/
GBD 2017 Viral Hepatitis Collaborators. The global, regional, and national burden of viral hepatitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020 Mar 28;395(10225):1230–1253. doi:10.1016/S0140-6736(20)30541-8.
Secretaria da Saúde do Estado do Ceará. Boletim Epidemiológico Hepatites Virais 2024 [Internet]. Fortaleza: SESA-CE; 2024 [citado 2025 Jan 26]. Disponível em: https://www.saude.ce.gov.br/download/boletins/.
Brasil. Ministério da Saúde. Indicadores de hepatites [Internet]. Brasília: Ministério da Saúde; [data desconhecida] [citado 2025 jun 21]. Disponível em: https://indicadoreshepatites.aids.gov.br/
Hyppolito EB. Tratamento da hepatite C com DAAs - Caminhos para a eliminação da hepatite C no estado do Ceará [tese]. Fortaleza: Universidade Federal do Ceará; 2024.
Brasil. Ministério da Saúde. Sistema de Informação sobre Mortalidade (SIM) [Internet]. Brasília: Ministério da Saúde; [data desconhecida] [citado 2025 jun 21]. Disponível em: https://datasus.saude.gov.br/informacoes-de-saude/tabnet/.
Sociedade Brasileira de Hepatologia. Centros de referência [Internet]. [S.l.]: SBH; [data desconhecida] [citado 2025 jun 21]. Disponível em: https://sbhepatologia.org.br/centros-de-referencia/
Oliveira RJ, Bomfim HE, Macedo STM, Érico AGA, Távora LGF, Pires Neto RJ, et al. Efetividade de antivirais de ação direta no tratamento da coinfecção vírus da hepatite C e vírus da imunodeficiência humana. Cadernos ESP. 2023;17(1):e1346. Disponível em: https://cadernos.esp.ce.gov.br/index.php/cadernos/article/view/1346 DOI: https://doi.org/10.54620/cadesp.v17i1.1346
Hyppolito EB, Ramos Jr AN, Teixeira LP, Bezerra AM, Mendes LA, Silva TL, et al. Effectiveness and safety of direct-acting antivirals in the treatment of chronic hepatitis C: a real-life study in northeastern Brazil. Rev Soc Bras Med Trop. 2024;57:1-6. DOI: https://doi.org/10.1590/0037-8682-0192-2024
Celestino JH et al. O cenário epidemiológico da hepatite C no Brasil no contexto do plano nacional para eliminação da hepatite C até 2030 [internet] [resumo]. Braz J Infect Dis. 2023 [citado em 21 jun. 2025]; 27(S1): 139. Disponível em: https://www.sciencedirect.com/science/article/pii/S1413867023003367 DOI: https://doi.org/10.1016/j.bjid.2023.103076
Secretaria da Saúde do Estado do Ceará. Situação de saúde no Ceará [Internet]. Fortaleza: Secretaria da Saúde do Estado do Ceará; 2011 [citado 2025 jun 21]. Disponível em: https://www.saude.ce.gov.br/wp-content/uploads/sites/9/2018/06/livro_situacao_saude_ceara.pdf
Távora LGF, Hyppolito EB, Cruz JNM, Portela NMB, Pereira SM, Veras CM. Hepatitis B, C and HIV co-infections seroprevalence in a Northeast Brazilian center. Arq Gastroenterol. 2013;50(4):257-61. DOI:10.1590/S0004-28032013000400007. DOI: https://doi.org/10.1590/S0004-28032013000400007
Hyppolito EB, et al. Temporal trends and spatial patterns of hepatitis C-related mortality in Brazil. Rev Saude Publica. 2025 Mar 24;59:e1. doi:10.11606/s1518-8787.2025059006139. DOI: https://doi.org/10.11606/s1518-8787.2025059006139
Venkatesh R, Huang AS, Gurmessa K, Hsu EB. Understanding barriers to hepatitis C antiviral treatment in low-middle-income countries. Healthcare (Basel). 2024 Dec 30;13(1):43. DOI:10.3390/healthcare13010043. DOI: https://doi.org/10.3390/healthcare13010043
Choudhary NS, Saraf N, Saigal S, Rastogi A, Bhangui P, Thiagrajan S, et al. Outcome of hepatitis C-related liver transplantation in direct-acting antiviral era. Indian J Gastroenterol. 2020;39(6):539-43. DOI:10.1007/s12664-020-01105-z. DOI: https://doi.org/10.1007/s12664-020-01105-z
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Accepted 2025-06-25
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