HOSPITAL MICROBIOLOGICAL PROFILE BEFORE AND DURING COVID-19
DOI:
https://doi.org/10.54620/cadesp.v19i1.2115Keywords:
COVID-19, Antimicrobial Stewardship, Drug Resistance, MicrobialAbstract
Objective: To compare the microbiological profile of cultures from patients hospitalized in a private hospital in Fortaleza, CE, before (2018/19) and during the COVID-19 pandemic (2020/21). Methods: Descriptive and analytical cross-sectional study using secondary data from an antimicrobial stewardship program. Patients aged over 18 years with cultures collected during the study period were included, excluding one case with incomplete data. Data were tabulated in Excel and analyzed using StataSE. Results: There was a predominance of male patients aged 19 to 59 years. The microbiological profile showed a reduction in the number of positive cultures, an increase in the number of isolated fungal and an increase antimicrobial resistance during the pandemic. Carbapenem-resistant Acinetobacter baumannii isolates increased from 50.88% to 79.83%, and Klebsiella pneumoniae from 29.09% to 54.64%. Conclusion: The COVID-19 pandemic contributed to an increase in antimicrobial resistance, highlighting the need to intensify microbiological surveillance.
Downloads
References
Loureiro RJ, Roque F, Teixeira Rodrigues A, Herdeiro MT, Ramalheira E. O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução. Revista Portuguesa de Saúde Pública [Internet]. 2016 [citado 28 de julho de 2022];34(1):77–84. Disponível em: https://www.sciencedirect.com/science/article/pii/S087090251500067X
Monteiro RF dos S, Santos VRR dos, Ferreira AACT, Abreu JRG de. O uso indiscriminado de antimicrobianos para o desenvolvimento de micro-organismos resistentes. REAS [Internet]. 23jul.2020 [citado 28 de julho de 2022] ;(53): e3597. Disponível em: https://acervomais.com.br/index.php/saude/article/view/3597
European Centre for Disease Prevention and Control. Antimicrobial resistance and consumption remains high in the EU/EEA and the UK, according to new ECDC data. 2020. [Internet].18nov.2020 [citado 28 de julho de 2022]. Disponível em: https://www.ecdc.europa.eu/en/news-events/antimicrobial-resistance-and-consumption-remains-high-press-release
World Health Organization. No time to Wait: Securing the future from drugresistant infections.[Internet] 29april.2019. [citado 28 de julho de 2022]. Disponível em: https://www.who.int/publications/i/item/no-time-to-wait-securing-the-future-from-drug-resistant-infections
Alshaikh FS, Godman B, Sindi ON, Seaton RA, Kurdi A. Prevalence of bacterial coinfection and patterns of antibiotics prescribing in patients with COVID-19: A systematic review and meta-analysis. PLOS ONE [Internet]. 2022 [citado 12 de fevereiro de 2024];17(8):e0272375. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272375
Santos CVB dos, Cavalcante JR, Pungartnik PC, Guimarães RM. Transição da idade de casos, internações e óbitos em internações por Covid-19 no município do Rio de Janeiro. Rev Bras Estud Popul [Internet]. 2022 [citado 12 de fevereiro de 2024];39:e0195. Disponível em: https://www.scielo.br/j/rbepop/a/WNVdGDC8rrD5FNNPm3jDGLP/
World Health Organization. Preventing the COVID-19 pandemic from causing an antibiotic resistance catastrophe. 2020 [citado 28 de julho de 2022]. Disponível em: https://www.who.int/europe/news/item/18-11-2020-preventing-the-covid-19-pandemic-from-causing-an-antibiotic-resistance-catastrophe
Silva RFD. Impacto da pandemia da COVID-19 no perfil de resistência bacteriana em um hospital da cidade do Natal-RN [Dissertação]. [Rio Grande do Norte]: Programa de Pós-Graduação em Biologia Parasitária da Universidade Federal do Rio Grande do Norte; 2022.
Gangneux JP, Bougnoux ME, Dannaoui E, Cornet M, Zahar JR. Invasive fungal diseases during COVID-19: We should be prepared. J Mycol Med [Internet]. 2020 [citado 12 de fevereiro de 2024];30(2):100971. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136887/
Toledo AG. Infecções fúngicas em pacientes internados com COVID-19: uma revisão de literatura. 2022 [citado 30 de setembro de 2023]; Disponível em: http://hdl.handle.net/11449/217172
Gomes AAG, Da Silva MR, Garcês TCDCS, Pinto ASB, De Andrade SMO, Saraiva ER, et al. Infecções relacionadas à assistência em saúde em unidades de terapia intensiva no Brasil. Acervo Saúde [Internet]. 2020 [citado 13 de fevereiro de 2024];12(11):e4665. Disponível em: https://acervomais.com.br/index.php/saude/article/view/4665
Zhu H, Swierstra J, Wu C, Girard G, Choi YH, van Wamel W, et al. Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils. Microbiology (Reading). 2014;160(Pt 8):1714–25.
Hussar YL. Perfil de utilização de antimicrobianos de uso restrito e resistência bacteriana durante a pandemia de COVID-19 na UTI do Hospital Santa Casa da Misericórdia de Ouro Preto-MG [dissertação]. Ouro Preto: Universidade Federal de Ouro Preto; 2022. Disponível em: http://www.monografias.ufop.br/handle/35400000/5203
Mesquita RF, Lima CAL de O, Lima LVA, Aquino BP, Medeiros MS. Rational use of antimicrobials and impact on the microbiological resistance profile in times of pandemic by Covid-19. RSD [Internet]. 2022Jan.16 [cited 2025Jan.25];11(1):e58211125382. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25382
Li J, Wang J, Yang Y, Cai P, Cao J, Cai X, et al. Etiology and antimicrobial resistance of secondary bacterial infections in patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis. Antimicrob Resist Infect Control. 2020;9(1):153.
Huttner BD, Catho G, Pano-Pardo JR, Pulcini C, Schouten J. COVID-19: don’t neglect antimicrobial stewardship principles! Clin Microbiol Infect. 2020;26(7):808–10.
Alves Araújo L, Dos Santos LS, Araújo Da Silva FD, Souza Oliveira JV. Implicações do gerenciamento de antimicrobianos em um hospital público. Cadernos ESP [Internet]. 13 de setembro de 2024 [citado 9 de dezembro de 2024];18(1):e1936. Disponível em: https://cadernos.esp.ce.gov.br/index.php/cadernos/article/view/1936
Additional Files
Published
How to Cite
Conference Proceedings Volume
Section
Categories
License
Copyright (c) 2025 Cadernos ESP
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2025-07-14
Published 2025-08-07
